Biography
I received my PhD in Biomedical Sciences and Bioinformatics from the University of California (UC) San Diego. My research interests center on harnessing the power of human genetics and computational genomics to uncover and validate novel therapeutics. Outside of work, you can find me rock climbing, playing tennis, or training for my next triathlon.
Interests
- Statistical genetics
- Computational genomics
- Functional genomics
- Metabolic disease
Education
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PhD in Biomedical Sciences with Specialization in Bioinformatics, 2023
Univ. of California San Diego
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BSc in Pharmaceutical Chemistry, Minor in Quantitative Biology & Bioinformatics, summa cum laude, 2018
Univ. of California Davis
Skills
Proficiency in scripting languages (R, Python)
Next-generation sequencing (NGS), RNA-seq, ATAC-seq, ChIP-seq analysis
High performance computing, Git version control
Human population genetics
Biostatistics
Written and oral communication
Publications and Presentations
(2023).
Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL cholesterol ratio.
Manuscript under journal peer review, November 2023.
(2023).
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins.
Cell Genomics, May 2023.
(2023).
Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.
Journal of Biological Chemistry, March 2023.
(2022).
A seven-transmembrane protein-TM7SF3 resides in nuclear speckles and regulates alternative splicing.
iScience, November 2022.
(2022).
Activation of PPARG in skeletal muscle and visceral adipose tissues ameliorate NASH biomarkers in humans: implications for therapeutic targeting.
[Poster session], Keystone Conference: Inter Organ Crosstalk in NASH. Whistler, Canada.
(2022).
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of multiple cardiovascular disease risk factors.
[Poster session], Mutational Scanning Symposium. Toronto, Canada / Virtual.
(2022).
Genetics of Type 2 Diabetes: Implications from Large-Scale Studies.
Current Diabetes Reports, March 2022.
(2021).
Human Genetics to Identify Therapeutic Targets for NAFLD: Challenges and Opportunities.
Frontiers in Endocrinology, December 2021.
(2020).
In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation.
Drug Metabolism and Disposition, December 2020.
(2019).
Characterization of Hepatocytes Uptake Clearance of Organic Anion Transporting Polypeptide (OATPs) Substrates in Human and Cynomolgus Cryopreserved Hepatocytes.
Federation of American Societies for Experimental Biology (FASEB), April 2019.
Experience
Graduate Student Researcher
Research Intern
Gilead Sciences
Research Intern
Cytokinetics
Honors Undergraduate Researcher
Laboratory of Dr. Xi Chen
Clinical Data Intern
Pharmacyclics, an AbbVie company
Awards
Institutional National Research Service Award (T32) Grant Recipient
Best Poster Awardee - 2nd Place
Departmental Highest Honors Research Award
Thesis: Chemoenzymatic Synthesis of Sialyl Lewis X, A Biologically Important Tetrasaccharide, and the Cloning and Characterization of Enzymes for Carbohydrate Synthesis