Publications

N DeForest, Z Zhu, J Dron, P Natarajan, J Olefsky, J Flannick, T Amariuta, G Peloso, A Majithia (2023). Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL cholesterol ratio. Manuscript under journal peer review, November 2023.

N DeForest, B Kavitha, S Hu, R Issac, L Krohn, M Wang, X Du, CDA Saldanha, J Gylys, E Merli R Abagyan, L Najimi, V Mohan, Alnylam Human Genetics, AMP-T2D Consortium, J Flannick, GM Peloso, P Gordts, S Heinz, AM Deaton, AV Khera, J Olefsky, V Radha, AR Majithia (2023). Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins. Cell Genomics, May 2023.

G Trieger, A Pessentheiner, S Purcell, CR Green, N DeForest, K Willert, A Majithia, C Metallo, K Godula, P Gordts (2023). Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism. Journal of Biological Chemistry, March 2023.

R Isaac, Y Vinik, M Mikl, S Nadav Eliyahu, H Shatz Azoulay, A Yaakobi, N DeForest, A Majithia, N Webster, Y Shav Tal, E Elhanany, Y Zick (2022). A seven-transmembrane protein-TM7SF3 resides in nuclear speckles and regulates alternative splicing. iScience, November 2022.

N DeForest, AR Majithia (2022). Activation of PPARG in skeletal muscle and visceral adipose tissues ameliorate NASH biomarkers in humans: implications for therapeutic targeting. [Poster session], Keystone Conference: Inter Organ Crosstalk in NASH. Whistler, Canada.

Conference Webpage

N DeForest et. al (2022). Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of multiple cardiovascular disease risk factors. [Poster session], Mutational Scanning Symposium. Toronto, Canada / Virtual.

Conference Webpage

N DeForest, AR Majithia (2022). Genetics of Type 2 Diabetes: Implications from Large-Scale Studies. Current Diabetes Reports, March 2022.

X Du, N DeForest, AR Majithia (2021). Human Genetics to Identify Therapeutic Targets for NAFLD: Challenges and Opportunities. Frontiers in Endocrinology, December 2021.

X Liang, Y Park, N DeForest, J Hao, X Zhao, C Niu, K Wang, B Smith, Y Lai (2020). In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In Vitro to In Vivo Extrapolation. Drug Metabolism and Disposition, December 2020.

X Liang, N DeForest, Y Park, J Hao, X Zhao, Y Lai (2019). Characterization of Hepatocytes Uptake Clearance of Organic Anion Transporting Polypeptide (OATPs) Substrates in Human and Cynomolgus Cryopreserved Hepatocytes. Federation of American Societies for Experimental Biology (FASEB), April 2019.